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Thrombosis in Patients with Acquired Immunodeficiency Syndrome
Jaehoon Lee, M.D, Wan Beom Park, M.D. and Kang Won Choe, M.D.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Vol.39 Num.6 (p338~341)
Patients with HIV infection may be at increased risk of thrombosis. A variety of mechanism have been proposed to account for hypercoagulability in HIV-infected patients. These include decreased plasma concentrations of protein S, opportunistic infection, tumor such as Kaposi's sarcoma, drugs such as megestrol acetate, protease inhibitor, and presence of anticardiolipin antibody. The authors report three cases of thrombosis in AIDS patients. One case was renal vein thrombosis associated with abnormalities of protein S and anticardiolipin IgG. Two cases were pulmonary embolism associated with megestrol acetate.
Keywords : Thrombosis, Hypercoagulability, Megestrol acetate, AIDS