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Chemoprophylaxis and Serological Follow-Up in Brucella abortus Exposed Laboratory Workers
Chang-Seop Lee, M.D.1,3,4, Hye-Soo Lee, M.D.2,3, Jae-Hyeon Lee, M.D.2, Jin-Hee Park, Ph.D.3, Young-Sil Choi5, Kyu-Jam Hwang, Ph.D.5 and Heung-Bum Lee, M.D.1,3
Department of Internal Medicine1 and Laboratory Medicine2, Chonbuk National University Medical School, Research Institute of Clinical Medicine3, Chonbuk National University, Department of Infection Control4, Chonbuk National University Hospital, Jeonju, Division of Zoonoses, Center for Immunology and Pathology, National Institute of Health5, Seoul, Korea
Vol.40 Num.2 (p107~109)
The aerozolization is one of possible Brucella transmission mechanisms, particularly in air-borne exposed laboratory workers. In this study, seven laboratory workers were potentially exposed to B. abortus via aerosols. Two laboratory workers who sniffed an agar plate several times were considered to be at high risk for acquiring the disease, 5 workers who did not work directly with the strain were be considered at low risk of infection. Prophylactic antibiotics of doxycycline 200 mg/day and rifampin 600 mg/day were offered for 6 weeks in high risk workers and 3 weeks for low risk workers, respectively. Enrolled workers were advised to check for serological testing of Brucella species every 3 weeks during a total period of 12 weeks. Compliance with taking medicine was 57.1% (4/7) and compliance for completing the serological tests was 85.7% (6/7). None of the laboratory workers developed clinical disease or tested positive serologically during 3 months of serological testing and 1 year of clinical follow-up.
Keywords : Laboratory workers, Brucella spp., Chemoprophylaxis