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Invasive Aspergillosis of the Paranasal Sinuses Invading Skull Base: Successful Treatment with Voriconazole
Chai Ryoung Eun, M.D.1, Jung Yeon Heo, M.D.1, Ji Yun Noh, M.D.1, Young Kyung Youn, M.D.1, Hyun Joo Lee, M.D.2, Bong Kyung Shin, M.D.2, Jacob Lee, M.D.1, Joon Young Song, M.D.1, Hee Jin Cheong, M.D.1 and Woo Joo Kim, M.D.1
Department of Internal Medicine1, Pathology2, Korea University College of Medicine, Seoul, Korea
Vol.40 Num.2 (p110~115)
Skull base-invading, invasive aspergillosis is rare, but it is a potentially life-threatening disease. Nevertheless, the standard method and the optimal duration of treatment are not known yet. A 52-year-old female diabetic patient complained of ophthalmalgia and decreased visual acuity. MRI and CT scan revealed an enhancing mass in the right orbital fissure and showed an infiltrating process in the skull base around the right orbit apex and paranasal sinuses. The histological investigation revealed invasive aspergillosis of paranasal sinuses and the skull base. Clinical improvement occurred after marsupialization and post-operative systemic antifungal therapy with voriconazole for 14 weeks. We suggest that voriconazole treatment could show effective results for invasive aspergillosis of skull base and paranasal sinuses.
Keywords : Invasive aspergillosis, Skull base, Voriconazole