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Pharmacokinetics and Pharmacodynamics of Antibiotics: General Concepts and Recent Advances
Dong-Gun Lee, M.D., Ph.D.1 and Hyun-Ho Shin, M.S.2
Division of Infectious Diseases1, Department of Internal Medicine, Department of Biomedical Science2 College of Medicine, The Catholic University of Korea, Seoul, Korea
Vol.40 Num.3 (p140~147)
Pharmacokinetics (PK) of antibiotics can be considered as the absorption, distribution, and elimination of drug. Pharmacodynamics (PD) is the relationship between concentration of drug and the antimicrobial effect. Time course of antibiotic activity is a reflection of the interrelationship between PK and PD. Over the past decades, considerable data have been derived from in vitro, in vivo models and infected patients. The time course activity characteristics of concentration effect, and postantibiotic effects, determine the typical patterns of antibiotic activity according to the PD classification. Furthermore, the pattern of antibiotic activity over time is an important determinant of optimal dosage regimens. This review will focus on general concepts and the applications of PK/PD to antibiotic therapy.
Keywords : Pharmacokinetics, Pharmacodynamics, Antibiotics