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A Case of Oseltamivir-resistant Pandemic Influenza (H1N1 2009)
Hyo Lim Hong1, Ji Hun Kim1, Hwa Jung Yi2 and Hyun Hee Kwon1
Department of Internal Medicine1, Catholic University of Daegu, School of Medicine, Daegu; Division of Influenza Virus, Center for Infectious Diseases2, National Institute of Health, Centers for Disease Control and Prevention, Seoul, Korea
Vol.42 Num.2 (p103~106)
In April 2009, the first swine origin pandemic influenza (H1N1 2009) infection was reported in Mexico and United states and has since spread rapidly worldwide. Finally on June 11, 2009, WHO officially declared the first pandemic of the 21st century. Until March 2010, more than 213 countries reported laboratory confirmed cases of pandemic influenza H1N1 2009, including at least 16,931 deaths. The drug of choice for treatment and prophylaxis of pandemic (H1N1) 2009 influenza are the neuraminidase inhibitor (oseltamivir and Zanamivir). However, increased use of these drugs lead to the emergence of oseltamivir-resistant strains. We report a case of oseltamivirresistant pandemic influenza (H1N1 2009) virus infection in a patient who were initially started with oseltamivir for laboratory-confirmed influenza. Patient's symptoms worsened despite the use of high-dose oral oseltamivir, and antiviral susceptibility test showed oseltamivir resistance (H275Y mutation). The patient resolved after treatment with zanamivir.
Keywords : Pandemic, Influenza A, Oseltamivir, Resistance