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A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009) in a Patient with Acute Myeloid Leukemia
Yo Han Lee1, Hyo Youl Kim1, Hyun Soo Kim1, Young Uh2, Young Keun Kim1, Bo Ra Kim1, Ho Yeon Jung1, Woo
Departments of Internal Medicine¹ and Laboratory Medicine ², Yonsei University Wonju College of Medicine,
Vol.42 Num.2 (p107~111)
Oseltamivir is the drug of choice for patients with pandemic influenza (H1N1 2009). However, sporadic cases of oseltamivir resistance have been described worldwide. Up to March 2010, a total of 11 strains (2.2% of tested isolates) of oseltamivirresistant pandemic influenza (H1N1 2009) have been discovered in South Korea. We report a case of 46-year-old man with acute myeloid leukemia in whom an oseltamivir-resistant pandemic (H1N1) 2009 virus was isolated. Despite high dose oseltamivir therapy for 10 days he had persistent symptoms and showed positive results in repeated real-time RT-PCR for pandemic influenza (H1N1 2009) virus from nasopharyngeal specimen. The patient improved eventually after oseltamivir was replaced by zanamivir inhalation.
Keywords : Pandemic influenza (H1N1 2009), Oseltamivir, Antiviral resistance, Leukemia