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A Case of Bronchiolitis Obliterans Organizing Pneumonia Associated with Pandemic Influenza (H1N1 2009)
Min Hee Lim1, Sang Taek Heo1,4, Ho Cheol Kim1,4, In-Gyu Bae1,4, Jae hee Kim1, In-Suk Kim2,4, Sunjoo Kim2,4 and Gyung Hyuck Ko3,4
Departments of Internal Medicine1, Laboratory Medicine2 and Pathology3, and Gyeongsang Institute of Health Sciences4, Gyeongsang National University School of Medicine, Jinju, Korea
Vol.42 Num.2 (p112~116)
Several types of influenza-related pneumonia have been reported. Bronchiolitis obliterans organizing pneumonia (BOOP) is a nonspecific lung injury. A 64-yearold man sought care to an emergency room due to breathing difficulties. He was diagnosed with pandemic influenza (H1N1 2009) by the real-time polymerase chain reaction (PCR) and was suspected of concomitant bacterial
pneumonia. Therefore he was treated with oseltamivir and broad spectrum antibiotics. The disease progressed rapidly despite treatment, so a corticosteroid was added. The trans-bronchial lung biopsy was consistent with BOOP. Here, we investigated BOOP associated with the pandemic influenza (H1N1 2009) virus that was successfully treated with a combination of antiviral, antibacterial
and corticosteroid drugs. Although BOOP associated with influenza is rare, combined disease should be suspected especially when the pneumonia does not response to antiviral agents and antibiotics.
Keywords : Pandemic influenza, Bronchiolitis obliterans organizing pneumonia, Oseltamivir, Corticosteroid