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 Home > Available Issues |
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 Review Articles |
| IgE-Mediated Hypersensitivity Reactions to Cephalosporins |
| Baek-Nam Kim1 and You Sook Cho2 |
| Department of Internal Medicine1, Inje University Sanggye-Paik Hospital, Inje Uni versity College of Medicine; Division of Allergy and Clinical Immunology2, Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
Vol.42 Num.3 (p137~142)
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Cephalosporins are commonly prescribed either orally or parenterally for the treatment of bacterial infections because of wide safety margin compared with penicillins. Skin testing with a parent cephalosporin antibiotic has routinely been performed in Korea in the fear of developing anaphylaxis after the administration of a cephalosporin although penicillins are antibiotics that most commonly induce severe or life-threatening IgE-mediated reactions (anaphylaxis). In this review, we will discuss IgE-mediated hypersensitivity reactions to cephalosporins. Immunopathogenesis of IgE-mediated hypersensitivity reaction to cephalosporins, limitations of skin testing with parent cephalosporin antibiotics, and prescription strategy of cephalosporins for patients with a history of cephalosporin or penicillin hypersensitivity was described. |
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Keywords : Cephalosporins, Penicillins, Hypersensitivity, Anaphylaxis |
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