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 Case Reports |
| A Case of Cerebral Toxoplasmosis Following Tandem Autologous Stem Cell Transplantation in a Multiple Myeloma Patient |
| Kye-Hyung Kim, Kyoung-Ho Song, Jae Hyun Jeon, Wan Beom Park, Sang-Won Park, Hong Bin Kim, Nam Joong Kim, Inho Kim and Myoung-don Oh |
| Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea |
Vol.42 Num.3 (p181~186)
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Toxoplasmosis is a rare but fatal complication in hematopoietic stem cell transplant recipients, usually associated with allogeneic hematopoietic stem cell transplantation (HSCT). We report a case of cerebral toxoplasmosis in a patient with multiple myeloma, following tandem autologous stem cell transplantation. A 55-year-old Korean male presented with weakness in both legs that had progressed to both arms. A magnetic resonance imaging scan of the brain revealed multiple, variablesized ring-enhancing lesions with surrounding edema in the cerebral hemispheres and brain stem. Stereotactic biopsy revealed bradyzoites of Toxoplasma gondii in the brain tissue. The patient received trimethoprim-sulfamethoxazole, followed by pyrimethamine and sulfadiazine, accompanying treatment for progressive multiple myeloma. Cerebral toxoplasmosis should be considered as one of the differential diagnoses in patients with neurologic signs following autologous HSCT. |
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Keywords : Toxoplasmosis, Cerebral, Stem cell transplantation, Autologous, Multiple myeloma |
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