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 Original Articles |
| Prevalence of Extended-spectrum β-lactamase among Enterobacteriacae Blood Isolates with Inducible AmpC β-lactamase |
| Hae Suk Cheong1, Kwan Soo Ko2, Cheol-In Kang3, Doo Ryeon Chung3, Kyong Ran Peck3, and Jae-Hoon Song3 |
| Division of Infectious Diseases, Konkuk University Hospital, Konkuk University School of Medicine1; Department of Molecular Cell Biology2 and Division of Infectious Disease3, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
Vol.42 Num.5 (p280~284)
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Background: Among the inducible AmpC β-lactamase-producing members of the family Enterobacteriaceae such as Enterobacter spp., Citrobacter spp., Serratia spp., and Morganella morganii (ECSM), the prevalence of ESBL-producing isolates are increasing. However, there have been only a limited number of studies that have investigated the prevalence for ESBL-production in blood isolates of these organisms.
Materials and Methods: We performed a prospective observational study to evaluate the prevalence for ESBL production among ECSM blood isolates. All consecutive blood isolates in the Samsung Medical Center were included from Oct 2006 to Mar 2008. Antimicrobial susceptibility test was performed by broth microdilution method. ESBLs were confirmed by double-disk synergy test and ESBL
phenotypes were determined by PCR.
Results: The 124 isolates (94 Enterobacter spp., 18 Citrobacter spp., 8 Serratia spp. and 4 Morganella spp.) were investigated. Among 124 ESCM isolates, 30 isolates (24.2%) showed ESBL-producing activity. Derepressed or partially derepressed AmpC mutants and derepressed AmpC mutants with ESBL production accounted for 36.3% (45/124) and 16.9% (21/124), respectively. Of ESBL producers, the most prevalent ESBL was SHV-12 (5/24, 20.8%).
Conclusions: The prevalence of ESBL-producing isolates is high in Enterobacter spp., Serratia marcescens and Citrobacter spp. clinical isolates. It suggested that routine screening test for ESBLs among Enterobacteriacae blood isolates with inducible AmpC β-lactamase should be needed. |
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Keywords : Enterobacter spp., Extended-spectrum β-lactamase, AmpC β-lactamase |
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