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Vitamin B12 Deficiency Megaloblastic Anemia in a Patient with Acquired Immunodeficiency Syndrome
Bongyoung Kim, Jieun Kim, Soonwoo Hwang, Yuhwa Lee, Junghwan Park, Shinje Moon, Jiyoung Choi, Juneseok Song, Jongheon Jeong, and Hyunjoo Pai
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
Vol.43 Num.3 (p266~269)
Anemia is the most common hematologic finding in patients with advanced infections caused by human immunodeficiency virus (HIV) or advanced acquired immunodeficiency syndrome (AIDS). Among many etiologies of HIVassociated anemia, vitamin B12 deficiency plays an important role, mostly due to malabsorption or HIV enteropathy. We experienced a case of megaloblastic anemia caused by vitamin B12 deficiency in a male patient with an AIDS who had no structural gastrointestinal problem. He showed severe anemia, leukopenia, thrombocytopenia and suspicious neurologic manifestations such as aggravation of dementia and gait disturbance. With vitamin B12 and folate treatment, the patient뭩 general condition and hematologic features were improved successfully.
Keywords : Human immunodeficiency virus (HIV), Megaloblastic anemia, Vitamin B12