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 Case Reports |
| Native Valve Infective Endocarditis due to Staphylococcus lugdunensis Confirmed by 16S Ribosomal RNA Sequencing |
| Young Eun Ha1, Seong-Yeol Ryu2, Kwan Soo Ko3,Eun-Jeong Joo1, So Yeon Park1, Hyun Ah Kim1, Min-Hee Lim1, Cheol-In Kang1, Doo Ryeon Chung1, Jae-Hoon Song1, Pyo-Won Park4, and Kyong Ran Peck1 |
| 1Division of Infectious Diseases, 3Department of Molecular Cell Biology, Samsung Biomedical Research Institute, 4Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 2Department of Infectious Disease, Keimyung University School of Medicine, Daegu, Korea |
Vol.43 Num.4 (p372~376)
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Staphylococcus lugdunensis is a Gram-positive, coagulase-negative Staphylococcus (CNS) species that is found as a skin commensal and has been implicated in fulminant invasive diseases such as infective endocarditis. S. lugudunensis infections resemble Staphylococcus aureus infections in terms of virulence, tissue destruction and clinical course. Although correct identification and determination of the susceptibility profile are important, some commercial systems may misidentify S. lugdunensis . We report a case of native valve infective endocarditis caused by S. lugdunensis , which was misidentified by the Vitek 2 system but identified correctly by 16S ribosomal RNA (rRNA) gene sequencing in a 72-year-old male patient. The patient had multiple vegetations on his mitral
valve, and the largest one was found on the posterior mitral valve leaflet. It was 2.5 cm in size and hypermobile. Diffuse valvular abscess was also observed. He had persistent bacteremia for appoximately 8 days, which was resolved after immediate surgery and antibiotic therapy. When a patient with severe sepsis syndrome grows S. aureus or CNS other than S. lugdunensis on a commercial automatic culture system, the possibility of S. lugdunensis should be considered and further confirmatory testing such as 16S rRNA sequencing may be very useful.
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Keywords : Staphylococcus lugdunensis , Infective endocarditis, Coagulasenegative staphylococci, 16S ribosomal RNA sequencing |
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