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Trend of Bacterial Resistance for the Past 50 Years in Korea and Future Perspectives – Gram-negative Bacteria
Kyungwon Lee1,2
Department of Laboratory Medicine1, and Research Institute of Bacterial Resistance2, Yonsei University College of Medicine, Seoul, Korea
Vol.43 Num.6 (p458~467)
The increasing prevalence of antimicrobial-resistant bacteria has become a serious problem in many parts of the world, including Korea. The resistance of of Grampositive cocci was once considered to be a more serious problem, but the recent emergence of multi-resistant Gram-negative bacilli has raised great concerns. In Korea, the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae and fluoroquinolone-resistant E. coli , K. pneumoniae, Acinetobacter spp., and Pseudomonas aeruginosa has gradually increased. The increase in imipenem resistance was slight in P. aeruginosa , but drastic in Acinetobacter spp. It is certain that problematic antimicrobial-organism combinations are prevalent in Korea, increase of resistant bacteria will continue in the future. The development of new antimicrobial agents is considered difficult. Therefore, it is very important to use existing antimicrobial agents prudently, to extend the efficacy, to prevent infections, and tostrengthen infection control measures to prevent spread of resistant bacteria.
Keywords : Bacterial resistance, Gram-negative bacteria, Korea