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 Original Articles |
| In Vitro Susceptibility of Aerobic Gram-positive Bacteria, Neisseria and Haemophilus influenzae |
| Yunsop Chong, Kyungwon Lee, Oh Hun Kwon |
| Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea |
Vol.12 Num.1 (p54~61)
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Dirithromycin is a novel derivative of erythromcyin with improvered pharmacokinetic properties. In this study, the in vitro activties of dirithromycin and other antimicrobial agents were compared against bacteria commonly isolated from respiratory and skin infections, Listeria monocytogenes and Neisseria. Overall, the activity of dirithromycin was similar to that of erythromycin. All of the Streptococcus pyogenes, S. agalactiae, L. monocytogenes, β-lactamase-negative N. gonorrhoeae and majority of the methicillin-susceptible Staphylococcus were susceptible to dirithromycin. From the similar in vitro activity, but better pharmacokinetic properties of dirithromycin compared to erythromycin, it is concluded that dirithromycin may be more useful than erythromycin for the treatment of community-acquired respiratory, genital and skin infections.
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