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 Original Articles |
| Efficacy and Toxicity of Single Dose Versus Multiple Doses of Doxycycline for Tsutsugamushi Disease |
| Jun Hee Woo, Hyun Tai Kim, Yunkee Yum |
| Department of Internal Medicine and Pharmacy, Soon Chun Hyang University Hospital, Seoul, Korea |
Vol.12 Num.1 (p70~74)
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Tsutsugamushi disease(scrub typhus) is an acute febrile infectious disease caused by R. tsutsugamushi transmitted by chiggers, that is larvae of trombiculid mite (Leptotrombidium akamushi and L. delinese).
It is characterized by a lesion at the site of the bite of an infected mite, a fever of 2 weeks' duration, and cutaneous rash.
Tetracycline, doxycycline and chloramphenicol are all effective in scrub typhus. The drug should be continued for at least 2 days after the patient has become afebrile.
We investigated the efficacy of single dose of doxycycline for 21 case of scrub typhus versus long term multiple doses of doxycycline for 28 patients of scrub typhus.
There were no statisitical differences between the two treatment groups in clinical success rate(85.7% in single dose vs 89.3% in longterm group) (p>0.05)
There were 2 cases of relapse in both groups.
A single dose of 200mg of doxycycline is as effective as longterm multiple doses of doxycycline in patients with scrub typhus.
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