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 Original Articles |
| High Level Aminoglycoside Resistance of Enterococci Isolated from Pediatric Patients |
| In A Cha, Jong Hee Shin, Soon Pal Suh, Dong Wook Yang |
| Department of Clinical Pathology, Chonam University Medical School, Kwangju, Korea |
Vol.12 Num.1 (p75~83)
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In recent years, increasing numbers of enterococcal isolates have acquired high-level resistance to aminoglycoside. High-level resistance to aminoglycoside is clinically relevant in that it eliminates the synergism between cell wall active agents and aminoglycoside against enterococci. We evaluated the prevalence rate and the risk factors of high level resistance in enterococci isolated from pediatric patients.
Fifty six enterococcal strains isolated from pediatric patients at Chonnam University Hospital were examined by single-concentration agar dilution method for resistance to gentamicin(500μg/ml), kanamycin(2,000μg/ml), and streptomycin (2,000μg/ml).
Hige-level resistance rate to one or more aminoglycosides was 85.7%(48.56); 30 strains(53.6%) showed resistance to all three aminoglycosides and 12 strains(21.4%) to gentamicin and kanamycin. Resistance rates to kanamycin, gentamicin, and streptomycin were 83.9%, 76.8%, and 62.5%, respectively. Longer hospital days(more than 72 hours) prior to culture, especially in neonates, was a significant risk factor for high level aminoglycoside resistance of enterococci.
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