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 Original Articles |
| In Vitro Activities of Astromicin Against Gentamicin-Resistant Aerobic Gram-Negative Bacilli |
| Yang Ree Kin, Jin Hong Yoo, Wan Shick Shin, Jin Han Kang*, Moon Won Kang |
| Department of Internal Medicine and Pediatrics*, Catholic University Medical College, Seoul, Korea |
Vol.12 Num.2 (p116~122)
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Aminoglycosides have been widely used in many aerobic gram-negative infections, but their use is limited by development of resistance and toxicities.
Astromicin is known to be a new aminoglycoside that is less influenced by aminoglycoside-modifying enzymes and has relatively low toxicity. We evaluated in vitro activities of astromicin against 413 strains of gentamicin-resistant aerobic gram-negative bacilli(63 strains of A. baumannii, 60 strains of E. coli, 56 strains of E. cloacae, 82 strains of K. pneumoniae, 60 strains of P. aeruginosa, 60 strains of S. marcescens, 16 strains of C. freundii, and 16 strains of P. mirabilis) with standard agar dilution method, and compared with other 3 aminoglycosides; tobramycin, amikacin, and arbekacin.
Astromicin is two to eightfolds as effective as amikacin against C. freundii, E. cloacae, E. coli, K. pneumoniae, and P. mirabilis. In vitro activity of astromicin against A. baumannii is better than that of amikacin, but worse than that of arbekacin. It has better activity against S. marcescens compared with amikacin and arbekacin. Amikacin shows best activity against P. aeruginosa. Tobramycin has poor activity against all organisms in this study except E. coli.
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Keywords : Astromicin, Gram-negative bacilli, Antimicrobial activity |
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