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 Original Articles |
| Combined Effect of Rifampin with Other Agents against Methicillin-Resistant Staphylococcus aureus |
| Yong Lim |
| Department of Microbiology, Chosun University College of Medicine, Kwangju, Korea |
Vol.12 Num.2 (p123~132)
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Though infections with methicllin-resistant Staphylococcus aureus(MRSA) have become more prevalent in community hospitals thorughout the world, current therapeutic antimicrobial regimens for MRSA strains have not well established. This study was carried out using rifampin as a core drug in combination with several other antimicrobial agents.
Susceptibility of 28 clinical isolates of MRSA to 19 antimicrobial agents was investigated by agar dilution method. Norfloxacin, vancomycin, and fusidate inhibited the growth of all strains at concentrations ranging from 0.25 to 2μg/ml, 1 to 4μg/ml, and 0.015 to 0.06μg/ml respectively. Doxycycline and cefamandole revealed relatively good antimicrobial activities with MIC90s of 16 and 32μg/ml, respectively. All of tested 28 strains of MRSA were resistant to rifampin, cefotiam, ceftazidime, tobramycin, and erythoromycin (MIC90 greater than 128μg/ml).
The combination of rifampin with cefamandole, doxycycline, norfloxacin, vancomycin, or fusidate was evaluated by checkerboard agar dilution method against methicillin and rifampin-resistant Staphylococcus aureus. The best synergistic effect was observed with combination of rifampin and cefamandole in 24 strains(85.7%). Rifampin-doxycyline was synergistic against 21 stains(75.0%) and not antagonistic against all strains. Rifampin-norfloxacin and rifampin-fusidate were synergistic against 9 strains(32.1%) and 3 strains(10.7%) and antagonistic against 4 strains(14.3%) and 5 strains(17.9%), respectively. Rifampin-vancomycin was synergistic against only 2 strains(7.2%) and antagonistic against 17 strains (60.7%).
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