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 Original Articles |
| In Vitro Activities of Tosufloxacin Against Aerobic Gram-negative Bacilli |
| Moon Soo Lee, Yun Sop Chong |
| Department of Surgery, College of Medicine, Soon Chun Hyang University, and Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea |
Vol.13 Num.1 (p56~64)
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Tosufloxacin, one of the fluoroquinolones with broad-spectrum activity, became available lately. Gradual increase of fluoroquinolone resistance has been reported in some species of bacteria with the increased use of the drug, but the in vitro activity of tosufloxacin against our clinical isolates has not been evaluated. In this study, the activity against aerobic gram-negative bacilli were tested by the agar dilution method. MIC90s of tosufloxacin were ≤1 μg/ml against Klebsiella oxytoca, Enterobacter aerogenes, Proteus vulgaris, Morganella morganii, Salmonella, Shigella flexneri and Yersinia enterocolitica, less than 16 μg/ml against Citrobacter freundii, K. pneumoniae, E. cloacae, P. mirabilis, Providencia spp. and Xanthomonas maltophilia, and over 16μg/ml against Escherichia coli, Serratia marcescens, Acinetobacter baumannii and Pseudomonas aeruginosa. Resistance rates to tosufloxacin, ciprofloxacin and ofloxacin were similar except for Providencia spp. and X. maltophilia, which were lower to tosufloxacin. Tosufloxacin may be as useful as ciprofloxacin and ofloxacin especially for the treatment of enteric bacterial infections.
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