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 Case Reports |
| Two Cases of Escalated M-VAC Therapy in Refractory Metastatic Transitional Cell ca. of the Bladder |
| Yong Hyun Cho, Byeong San Kwon, Ji Youl Lee, Sae Woong Kim, Choong Bum Lee and Moon Soo Yoon |
| From the Department of Urology, Catholic Universiy Medical College, Seoul, Korea |
Vol.15 Num.3 (p337~343)
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Background : M-VAC(methotrexate, vinblastine. doxorulbicin, cisplatin) chemotherapy is the most common and effective treatment modality for advanced transitional bladder tumor. However, there is no effective therapy in case of the patients with bladder tumor refractory to M-VAC chemotherapy.
Methods : Two male patients with metastatic transitional bladder tumors refractory to conventional chemotherapy with methotrexate, vinblastine, doxorubicim, and cisplatin (M-VAC) were treated with escalate3 dose of M-VAC plus recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF). Formula of escalated M-VAC chemotherapy were 30mg/m2 of methotrexate, 4mg/m2 of vinblastine. 60mg/m2 of doxorubicn, and 100mg/m2 of cisplatin, and 250mg/m2 rhGM-CSF per day administered subcutaneously (SC) for 10 consecutive days.
Result : One of the treated patients was responded with complete remission and the other one m-as dead by sepsis on post-escalated M-VAC chemotherapy 14 days.
Coclusion : We believe escalated M-VAC chemotherapy may be one of the effective alternative treatment for patients with metastatic urothelial tumor refractory to conventional M-VAC chemotherapy.
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Keywords : Escalated M-VAC, rhGM-CSF, Transitional cell carcinoma, Bladder |
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