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 Original Articles |
| In Vitro Susceptibilities of Bacteroides Fragilis Group Organisms to Several Antimicrobial Agents, Including Cefepime |
| Jeong Won Shin, Nam Jae Park, Kyungwon Lee, Yonsop Chong, and Jang Hwan Cho |
| Department of Clinical Pathology and Surgery, Yonsei University College of Medicine, Seoul, Korea |
Vol.16 Num.1 (p23~31)
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Background : Bacteroides fragilis group (BFG) organisms, the most commonly isolated anaerobes from clinical specimens, are more frequently resistant to antimicrobial agents than other anaerobes. The aim of this study was to determine the susceptibility of BFG organisms to various antimicrobial agents including cefepime.
Methods : Antimicrobial susceptibility of 136 BFG organisms, which were isolated in 1995 and 1996 from various clinical materials and consisted of 88 B. fragilis, 28 B. thetaiotaomicron, 7 B. ovatus, 7 B. uniformis, 4 B. distasonis, 2 B. vulgatus, were tested by the NCCLS agar dilution method using Wilkins Chalgren agar. The plates were incubated in an anaerobic chamber for 48 h before reading the results.
Results : The resistance rates to cefotaxime were 33-82% depending on the species. The resistance rates to cefotetan varied markedly depending on the species of the BFG organisms and the resistance rates were 9% for B. fragilis. 79% for B. thetaiotaomicron and 85% for other BFG species. The resistance rates were higher than those in 1994. The resistance rates to cefoxitin were: B. fragilis. 1% ; B. thetaiotaomicron, 14%; other BFG species, 10%, although no isolate showed resistance to cefoxitin in 1994. The MIC90S of the cefepime were >128 ㎍/mL against all BFG organisms, and the resistance rates were 85-100%. No isolates were found to be resistant to imipenem, chloramphenicol and metronidazole.
Conclusion : The increased resistance to cefotaxime, cephamycin and clindamycin indicates that routine antimicrobial susceptibility test of these drugs is needed before using the drugs, and the high MIC value to cefepime suggests that it would not be useful for the treatment of anaerobic infection.
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Keywords : Bacteroieds fragilis group (BFG) organism, Antimicrobial susceptibility, Cefepime |
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