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 Original Articles |
| Piperacillin-Tazobactam Effect on the Piperacillin and Ceftazidime Resistant P. aeruginosa and A. baumanii |
| Jeoung Ki Choi, Heung Bum Lee, Yong Chul Lee, and Yang Keun Rhee |
| Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Korea |
Vol.16 Num.1 (p43~49)
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Background : Tazobactam is a penicillanic acid sulfone β-lactamase inhibitor with a structure similar to that of sulbactam. It is available for parenteral administration only in combination with piperacillin, which has the best in vitro activity against Pseudomonas aeruginosa among the antipseudomonal penicillins. However, piperacillin was destroyed by Staphylococcus aureus, Escherichia coli, Klebsiella and Bacterioides species induced β-lactamases. This study was designed to assess the efficacy and safety of piperacilhn-tazobactam against piperacilline and ceftazidime resistant P. aeruginosa and Acinetobacter baumanii.
Methods : Piperacillin-tazobactam was given intravenously every 8 hours combined with aminoglycoside to 12 hospitalized patients with a lower respiratory tract infection.
Results : There were favorable responses in 5 cases. Complete eradication of causative pathogen was noted in 3 cases in the only P. aeruginosa infected group. There were adverse reactions in 3 cases, which included a febrile reaction and 2 cases of upper gastrointestinal bleedings. The piperacillin-tazobactam in six unfavorable cases was antibiotic changed to imipenem.
Conclusion : In piperacillin and ceftazidime resistant lower respiratory infection, piperacillin-tazobachm can be chosen as an antibiotics to control infection before administration of imipenem
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Keywords : Piperacillin-tazobactam, Piperacillin and ceftazidime resistant, P. aeruginosa and A. baumanii |
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