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 Original Articles |
| Antipneumococcal Activity of the Novel Quinolone CFC-222 Compared to Other Drugs by MIC and Time-kill |
| Hyuk Lee*, Jong Seong Kim*, Joung Hwa Jin, Ji Won Yang, Shin Woo Kim, Sungmin Kim, Kyong Ran Peck, and Jae Hoon Song |
| Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University, Seoul;
Department of Internal Medicine, Dong-A University College of Medicine, Pusan, Korea*
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Vol.17 Num.2 (p121~128)
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Background : CFC-222 is a new fluoroquinolone which possesses a broad antibacterial activity, being especially potent against gram-positive bacteria as well as gram negative bacteria. To evaluate the in vitro activity and the bactericidal killing rate of CFC-222 against Streptococcus pneumoniae, agar dilution test and lime-kill study was performed.
Method : 200 clinical isolates were tested by agar dilution method to determine MICs of penicillin, cefotaxime, meropenem, ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin, and CFC-222. Time-kill studies were performed with 8 pneumococcal isolates (2 penicillin-susceptible, 2 intermediate, and 4 resistant) to compare the bactericidal activity of penicillin, sparfloxacin, and CFC-222.
Results : MICs of cefotaxime and meropenem showed increasing tendency as penicillin MIC is increased. Of the quinolones tested, CFC-222 and sparfloxacin had the lowest MIC (MIC90 = 0.5 ㎎/mL), regardless of the penicillin-susceptibility of the strains. CFC-222 yielded 99.9 % killing of all penicillin-resistant strains after 8 h at 4 MIC, while penicillin and sparfloxacin were bactericidal after 12 h at 4 MIC.
Conclusion : By MIC and time-kill combined, CFC-222 and sparfloxacin were the most potent agents according to the MICs, whereas CFC-222 was more rapidly bactericidal than sparfloxacin against penicillin-resistant isolates.
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Keywords : CFC-222, Streptococcus pneumoniae, Time-kill assay |
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