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 Original Articles |
| The Effect of Pantoprazole on Peptic Ulcer and the Effect of Pantoprazole-based Triple Therapy on Eradicating Helicobacter pylori |
| Ok Jae Lee, Eul Jo Chung |
| Department of Internal Medicine & Gyeongsang Institute of Cancer Research, Gyeongsang National University College of Medicine |
Vol.19 Num.2 (p77~85)
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Background: Proton pump inhibitor-based triple therapies are effective for Helicobacter pylori (H. pylori) eradication. We studied the ulcer healing effect of pantoprazole and the effect of pantoprazole-based triple therapy according to clinical variables in eradicating H. pylori.
Methods: 24 patients with H. pylori-positive peptic ulcer received pantoprazole 40 ㎎, amoxicillin 1000 ㎎, and clarithromycin 500 ㎎, twice daily for a week and took pantoprazole 40 ㎎/day till complete healing of ulcer confirmed by gastroduodenoscopy. The status of iH. Pylori infection was assessed at least 4 weeks after completion of medication by rapid urease test, histology and 13C urea breath test.
Results: The ulcer healing rates were 76.5% at 5th week and 94.1% at 8th week. H. pylori eradication rates were 66.67% on intention to treat (ITT) analysis and 76.19% on per protocol (PP) analysis. The H. pylori eradication rates of pantoprazole-based triple therapy were 83.33% on ITT and 100% on PP analysis in patients with duodenal or duodenal/gastric ulcers, and 50% on ITT and 54.55% on PP in those with gastric ulcers (p=0.0164 (ITT), p=0.001 (PP)). However, there was no significant difference in eradication rates according to smoking, protocol, recurrence of ulcer, and hemorrhage. There was no serious side effect despite mild adverse events in 16.7% of the patients during triple therapy.
Conclusions: Pantoprazole was effective for healing of peptic ulcer. Pantoprazole-based triple therapy resulted in 76.2% of H. pylori-eradication rate, and was more effective for duodenal ulcers than gastric ulcers. There was no other clinical factor affecting eradication rate.
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Keywords : Peptic ulcer, Pantoprazole, Triple therapy, Helicobacter pylori, Eradication |
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