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 Case Reports |
| Cryptococcal meningitis in cardiac transplant patients. -The repot of two cases- |
| Jae Hyeong Park, Yun Jung Lee, Soo jin Kang, Young Hoon Jeong, Jin Seock Jang, Jun Won Chung, Sang-Ho Choi, Sun Jong Kim, Yang Soo Kim, Jae Joong Kim |
| Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center |
Vol.19 Num.3 (p341~347)
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Cryptococcal meningitis is a subacute or chronic mycotic infection caused by Cryptococcus neoformans and it is a second most common central nervous system (CNS) infection in organ transplant patients. The recent rise in incidence of the disease can be attributable to the wide use of immunosuppressive agents in organ transplant patients, the advent of acquired immunodeficiency syndrome (AIDS) patients and increased use of chemotherapeutic agents.
We report two cases of cryptococcal meningitis after cardiac transplantation. Their symptoms were not typical and neurologic examination was nonfocal. One patient had disseminated cryptococcal infection and invasive pulmonary aspergillosis, it might be associated with cytomegalovirus infection. They were diagnosed by cryptococcus latex agglutinin test and culture study with cerebrospin. thay fluid and treated with liposomal amphotericin B and oral fluconazole without any neurologic defects.
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Keywords : Heart transplantation, Cryptococcus neoformans, Cryptococcal meningitis. |
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