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Original Articles
Clinical Efficacy and Safety with Korea-Made Vancimycin Hydrochloride for Methicllin-Resistant Staphylococcus aureus Infection
Tae Hyong Kim1, Sang Ho Choi1, Mi Suk Lee2, Nam Joong Kim1, Yang Soo Kim1, Jiso Ryu1, Jun Hee Woo1, Yoon Ki Yom3
Division of Infectious Diseases, Asan Medical Center1, Department of Internal Medicine Ulsan University Hospital2, Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Chunan3, Korea
Vol.20 Num.4 (p313~321)
Background : Since the emergence of methicillin-resistant Staphylococcus aureus (NIRSA) in 1980s, vancomycin has been widely used as the antibiotic of choice for MRSA infections. Adverse events known as related with vancomycin are red-man syndrome, ototoxicity, and nephrotoxicity. We studied the clinical and bacteriological efficacy and safety of generic vancomycin (Cheiljedang vancomycin®) in the treatment of infections caused by MRSA.
Methods : During the period between April 1999 and September 2001, we prospectively enrolled 79 patients with established or suspected MRSA infection and evaluated the clinical and bacteriological efficacy and adverse events.
Results : Total 42 patients were evaluable for MRSA infections. MRSA pneumonia (14/42; 33.3%) was the most common diagnosis, followed by skin & soft tissue infection (9/42; 21.4%), primary bacteremia (5/42; 11.9%), and catheter-related infection (5/42; 11.9%). A favorable clinical response (cure or improved) occurred in 31 patients (75.6%) and a favorable bacteriological response (eradicated or presumed eradicated) occurred in 28 (68.3%) patients. MRSA infection related case fatality was 14.3%. The adverse events related to vancomycin were as follows; 2 patients (4.8%) with skin rash, 2 (4.8%) red-man syndrome, 2 nephrotoxicity, 2 leukopenia, and I thrombocytopenia.
Conclusion : These results suggest that Cheiljedang vancomycin hydrochloride could be effective and safe as treatment for severe infections caused by MRSA.
Keywords : MRSA (methicillin-resistant Staphylococcus aureus), Vancomycin, red-man syndrome, nephrotoxicity