Home > Current Issue
Case Reports
The First Case of Abacavir Hypersensitivity Associated with the HLA-B*57:01-Positive Allele in Korea
Ji Hyun Yoon, Mingoo Kim, Sung Joon Jin, Seung Kyu Kim, Seo Hui Lee, Jaeyoung Cheon, Gi young Yun, Min Kyung Kim, Jiyoon Ha, and Young Goo Song
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
On the 12th day of abacavir treatment, a 39-year old HIV-infected male patient was admitted with fever, generalized rash, abdominal pain, and watery diarrhea that had persisted for five days. Results of blood tests indicated rapid progression of hepatitis and renal failure. The day after stopping anti-retroviral therapy, his fever subsided and his liver function began to normalize. He was clinically diagnosed with abacavir hypersensitivity and was found to carry the HLA-B*57:01 allele. This is the first reported case of abacavir hypersensitivity associated with the presence of the HLA-B*57:01 allele in Korea.
Keywords : Abacavir, hypersensitivity, HLA-B*57:01, Korea