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Disseminated Invasive Aspergillosis with Multiple Brain Abscess after Allogeneic Hematopoietic Stem Cell Transplantation Treated Successfully with Voriconazole and Neurosurgical Intervention
Jae-Hyoung Im1, In Suh Park2, Eun Young Kim3, Jin Soo Lee1, Joo Han Lim1, Moon Hee Lee1, Chul Soo Kim1, Hyeon Jung Lee1, and Hyeon Gyu Yi1
Departments of 1Internal Medicine, 2Pathology, and 3Neurosurgery, Inha University College of Medicine, Incheon, Korea
Invasive aspergillosis is a serious infectious complication, which can occur after hematopoietic stem cell transplantation (HSCT). In particular, despite antifungal treatment, invasive aspergillosis involving the central nervous system (CNS) shows very high mortality. In principle, a neurosurgical procedure with an antifungal agent is recommended for treatment of CNS invasive aspergillosis. We encountered a patient suffering from disseminated invasive aspergillosis involving the lung, brain, and soft tissues after allogeneic HSCT for treatment of relapsed acute myeloid leukemia who was cured with voriconazole and stereotactic drainage of the brain abscess.
Keywords : Invasive aspergillosis, Central nervous system, Hematopoietic stem cell transplantation, Neurosurgical procedure, Voriconazole